Name of the Student
10th January 2018
Compound A is a carboxylic acid with a pKa of 5.0. The protonated form of A has a partition coefficient of 1.0. If A is ingested, indicate
a) its most likely site of absorption: stomach
b) the effect of achlorhydria on the absorption: absorption is reduced
c) the effect of administration of the compound immediately before and immediately after a substantial meal: before a meal, it is increased, but after a meal, it is reduced.
2. Why is insulin ineffective if given orally?
Since insulin is a polypeptide hormone, it can be digested by proteases in the gastrointestinal tract. Hence, insulin is not administered orally; rather, it is administered subcutaneously.
3.What is meant by the following terms:
ADME refers to absorption, distribution, metabolism, and excretion of a drug or a toxicant. It is an abbreviation for pharmacodynamics.
Xenobiotic is referred as any compound that is foreign to the body. It can either be a drug or a toxicant or a nutrient or a pollutant.
Systemic refers to any intervention that reaches different systems of the body through the arteries and veins.
Topical refers any intervention that is applied to the superficial surface of the body. Such applications are usually made to the dermal surface.
Biochemical Toxicology Introduction Week1.pptTUTORIAL 2
Patient C is a type I…
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