1.Describe tests that should be carried out to help evaluate the safety of a newly developed drug. 100 marks The common measures that are used to evaluate the safety of a newly developed drug in laboratory settings are LD50 and therapeutic index. Lethal Dose 50 or Median lethal dose is a test designed to determine the lethal status of various compounds. The LD50 value indicates the concentration of the drug that would kill half of a population that consumed it. It is used to determine the right amounts of prescription and avoid adverse effects of overdosing from newly developed drugs. Fixed Dose Procedure (OECD 420; 1992). This test relies on observing toxicity at a minimum fixed dose level to test...
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