Does Total Cholesterol and Cigarette Smoking Act as Suitable Predictors of MI: An analysis of Framingham Trial Subset Data

Does Total Cholesterol and Cigarette Smoking Act as Suitable Predictors of MI: An analysis of Framingham Trial Subset Data
Introduction
The Framingham Heart Trial is one of the most elaborative trials, which was conducted to evaluate the cardiovascular risk factors as all-cause morbidity and mortality. Various biochemical, cardiovascular and physical parameters were collected. These factors were correlated and regressed in various forms to understand the potential risk for cardiovascular ailments. These included stroke, myocardial infarction and coronary heart diseases.
The review of literature suggests that smoking leads to vasoconstriction and hence it may be speculated to cause constriction of coronary blood vessels leading to ischemia and myocardial infarction. On the other hand, cholesterol may form atherosclerosis in the coronary vasculature, which could narrow the lumen and may lead to decreased oxygen supply to myocardium, leading to infarction. The present study was done to evaluate a subset data of the Framingham Study. This was done to find out whether total cholesterol levels are significantly different in individuals who have a prevalent myocardial infarction compared to individuals who do not have a prevalent myocardial infarction. The study also aimed to evaluate whether prevalent myocardial infarction can be predicted from episodes of smoking and the total cholesterol levels.
Methodology
Sampling
Subset data were collected from the Framingham trial based on th…